Showing posts with label ToxicNews. Show all posts
Showing posts with label ToxicNews. Show all posts

Wednesday, 8 April 2020

We are in this situation because our governments and us (citizens) were irresponsible and selfish, respectively. A valid reflection on SARS-CoV-2 (as any other)

There's a massive, almost unprecedented for our times, health and economic crisis concerning the
upsurge of a viral pandemic (SARS-CoV-2) and everyone can read about it anywhere in the globe. Media are sucking dry this opportunity to report even on the minimal aspects to it related, some completely irrelevant, and some very well substantiated by reliable sources. Even though the numbers don't really add up when we cross-reference data obtained from different 'official' sources of information, it is almost impossible not to be adequately informed on the basics of its epidemiology, the impact on our financial systems and the different health aspects that relate immediately to covid-19 and us, patients.

Memes, images, funny videos, some outraged ones, a horde of multimedia interactions showing how the many different world populations are willing to respect the necessary quarantine/lock-down times, and also the typical uncivilised odd person breaking down with common sense and respect for others and going about their business with utter disrespect for the importance of (other) lives. Social networks and news web-platforms are populated with chronicles, speeches, conferences, discussions, forums, seminars, news; covid-19 has been distilled into so many formats that one can just find exactly what suits him/her best by picking from an immense pool of files left hanging around. 

Some of the distributed information speculate on how the virus spread, from where it spread from, debate on whether the Chinese government could have done more to avoid the repercussions of a viral spread turned into global pandemic, if there was a laboratory manipulation, if we are facing a biological weapon or merely the result of ubiquitous 5G technology in our lives. I could add in with my contribution to the technicalities of any theory where arguments fade to black the moment they arrive to the geographical and IT borders of China. After that horizon line, it is all but speculation because we simply aren't allowed to know more for censorship is active in said confinement. In addition, I dislike conspiracy theories if their purpose is to cause mayhem and chaos rather than debating a supported plausible scientific possibility. When the idea starts with, so and so said, I heard from, I believe and there is nothing to substantiate one's idea, the best thing is to just not participate in the stupidification of the masses.

I have my own theory that goes well beyond a simple zoonotic vectorisation of a virus. It accounts for an intention, it accounts for a purpose, it accounts for sloppiness, it accounts for irresponsibility, it accounts for a tripartite strategy, it accounts for immediate results, mid- and long-term objectives, it accounts for a myriad of participating valences that determined the global diaspora of contagious proportions we are presently dealing with.

Having said that I am of the opinion that most news media and governments, health and civil stakeholders are integrally now focused in finding a solution for the problem either based on a) understanding the dynamics of this virus and associated disease, b) reducing the impact on global finances, and 3) understanding how we went from patient zero to the mess we have presently in hands and that is to remain for the months to come.

Maybe because we are still living through such turmoil where the immediate concerns are, keeping people safe, alive and financially afloat, no one has yet looked in-depth to the evident trigger of this whole issue and the unpreparedness of our governments to deal with a boisterous elephant in the room (since 2002/2003). This epidemic turned pandemic did not come without a warning, we had numerous situations where the scientific community had warned of the likelihood of such health threat to reoccur. The number of available articles published since 2012 (if not before that) provided such a long list of whistling alerts. I hereby paste just a few for the sake of the example. A few!, culminating in two that everyone is talking about these days and that surprisingly, or not at all, indicated Wuhan as the most probable source of this pandemic... whilst the final one denies (based on the limited information presently available) any laboratory manipulation of this virus as the origin of its infectivity:

2002/2003 - SARS-CoV-1 epidemic.

2012 - Butler, D. (2012). "Clusters of coronavirus cases put scientists on alert - Surveillance ramped up after novel virus is identified in three Middle Eastern countries". Nature, 492, pp. 166-167.

2013 - Pebody, R., Zambon, M., Watson, J. M. (2013). "Novel coronavirus: how much of a threat?". BMS, 346(1), pp. 1756-1833.

2013 - Nuttall, I., Dye, C. (2013). "The SARS Wake-Up Call". Science, 339(6125), pp. 1287-1288.

2013 - Breban, R., Riou, J., Fontanet, A. (2013). "Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk". The Lancet, 382(9893), pp. 694-699.

2015 - Yang, X-L., Hu, B., Wang, B., Wang, M-N., Zhang, Q., Wu, L-J., Ge, X-Y, Zhang, Y-Z., Daszak, P., Wang, L-F., Shi, Z-L, Perlman, S. (2015). "Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus". Journal of Virology, 90(6), pp. 3253-3256.

2016 - Bhatia, P. K., Sethi, P., Gupta, N.,  Biyani, G. (2016). "Middle East respiratory syndrome: A new global threat". Indian J Anaesth60(2), pp. 85–88.

2019 - Fan, Y., Zhao, K., Shi, Z., Zhou, P. (2019). "Bat Coronaviruses in China". Viruses, 11(3), 210.

2020 - Andersen, K. G., Rambaut, A., Lipkin, I, Holmes, E. C., Garry, R. F. (2020). "The proximal origin of SARS-CoV-2". Nature Medicine, https://doi.org/10.1038/s41591-020-0820-9.

Amid a million questions that are still to find a scientific explanation, e.g., the death toll in Italy and Spain, etc., I have seen some surprising attitudes from both public and state representatives, like for example the current trendy embarrassing glorification of the national health services like they have been doing a great job with limited resources only since the start of this covid-19 problem. Most likely triggered by the fact that people are now a lot more tuned in with their own mortality. And I have seen a lot of other decoy interventionists talk about a wide array of subjects, but no one is talking about two incredibly relevant and clear aspects that need addressing, immediately or as soon as we clear up the dust around the stability of the different worldwide economies:

1) As it stands and considering the present available knowledge, this virus surfaced from a wet market populating with endangered exotic species. Due to the consumption of a mammal (bat) it spread disease to the many corners of the world in a fashion not so unprecedented, for we had dealt with a similar situation before (the cycle is repeating every 10 years or so). This virus has presently killed 81,478 humans all over the globe [1] and is the result of a combination of factors (policing and regulatory sloppiness, lack of hygiene, disrespect for endangered species, disrespect for animal lives, etc.), thus constituting a clear case of a CRIME AGAINST HUMANITY, and must be pondered based on that undeniable reality.

2) Governments had approximately two decades to have prepared for the likelihood that a SARS corona virus epidemic would reoccur, and what have we found out? No state was really prepared in logistic or any terms to successfully battle this problem, hence governments were forced to appeal to the most primary approach of quarantining and locking-down entire countries. The health services had to appeal to people's common sense to avoid an epic tragedy with global proportions, remote schooling was deficient in many aspects, companies where remote working is a natural possibility but that was never really looked into (in days of 'peace') were caught unprepared; and the unpreparedness is observed through so many different channels of our social existence. One is forced to ask, what was done with the information scientists had disclosed through the many years since 2002/2003? Disregarded? Ignored? Like the 2008 credit crunch, who is to pay the bill with rising unemployment, loss of property, loss of dignity, loss of stability, loss of freedom?, as we now understand how it is to be one of those caged animals in the wet market of Wuhan... devoid of liberty to choose, devoid of the most basic principle attributed to humans (thinking animals) since the moment they are born -  the right to life.

Now that we have some time in our hands to consider what it is to live enslaved and restricted of movements, with no choice but to wait for someone to decide for us on the worth of our most basic item  - our lives -, it is time to think that animals do not have any choice when people are out and about their business, treating animal lives as their own property.

Some contemporary social networking philosophers state this is a time of spiritual and emotional change and that people will learn new visions on the world that surrounds us. Utter Bullshit! The moment our doors open to going back to our 'normal' lives it will be business again for the savage caging and exploitation of animals, brutal killing of animals, the irrational use of animals to fulfill every single void in our egoistic lives...

And the only illation that one can obtain from this is that We are in this situation because our governments and us (citizens) were irresponsible and selfish, respectively.


[1] Coronavirus - Total confirmed covid-19 deaths, World, Our world in data, University of Oxford, [https://ourworldindata.org/coronavirus], last accessed on the 8th of April 2020, last update on the 8th of April 2020.

Tuesday, 12 November 2019

"Vaping nearly killed me, says British teenager", by BBC News

I thought it would be pertinent to share this brand new story that came out published online today in the BBC News website. I had already posted some information on the topic concerning the dangers associated to vaping and vaporisers, but more and more reports are coming out that show detrimental effects on lung tissue caused by vaping fumes/toxicants. The truth is that people have been now using these for a while and even though the so called long-term studies aren't still available, the first real-world data is starting to come out... and it doesn't look good.

If you'd like to revisit my post access HERE. For the BBC News story entitled "Vaping nearly killed me, says British teenager" please access HERE


Wednesday, 10 April 2019

Did you know that...

March is over, April is almost half-way done, Mother's Day is long gone now, and maybe over Easter time we can skip some Netflix or Amazon Prime easy entertainment to get our eyes on some very interesting reads. It's never easy to find enough time, I totally understand, but if you love science you always take some minutes to educate yourself. I myself am afflicted by very limited time to check all the science news that emerge daily like a Spring-scented garden. But if from a list of say, 14 interesting links, you pick a single one to really lay your eyes on, you will be automatically more informed than the moment that preceded it.

One single article may provide you with the information that you've been craving concerning that health issue you are affected by, that trick to get rid of fat stains from your new carpet, that medical advance that might be relevant for someone you know, or even that charity that is doing some philanthropic work in an African country that you've always wanted to visit... Who knows?, let the flow of an interesting article entice and seduce you into knowing a bit more science. A learned information cannot be unlearned, it will stay with you forever and one day might be useful.

Find below a list of topics I personally believe are extremely interesting with potential to draw a smile on your face today, for knowledge is not only power, knowledge is also very sexy!

Careers

The 2018 Employee Engagement Report for the Life Sciences Industry is live. Access it to read the 18 pages distilling the relevant information on key motivations and differential, company type, Management and Non-Management, Demographics, Type of contracts and the interesting findings observed. A very interesting reading for anyone on the industry, be it employee, and especially employers.

Environment

The Pacific plastic vortex is being cleaned up by System 001, a gigantic net created by the startup Ocean Cleanup to collect floating plastic from oceanic waters (Portuguese Language only). 

If you would like to know more on the plastic island floating through the pacific vortex read the post published by The Toxicologist Today in 2011.


Lifestyle

And if you're into diets, learn from specialists on how detrimental to one's health can it be the currently famous ketogenic diet (Portuguese language only).


And for those like myself, concerned with animal rights and the lack of options to wear, a great online shop I found for satiating your clothing desires.

Pharmaceuticals

A Universal flu vaccine is entering Phase 3 trial and intends to counteract known limitations of other vaccines against seasonal flu. BiondVax Pharmaceuticals apparently is leading the way towards a great prevention against the 8th leading cause of death that is costing America $87bn.

A new anti-malaria drug in the making; one that might actually be targeting the mosquito parasite at an early stage of life rather than focusing on the reduction of symptomatic impact. A good read with very promising results.


Research

Lego! Your children love eating those colourful plastic bricks at all times. But now a group of paediatricians decided to determine typical transit times for a swallowed Lego figurine head, as a matter of example.

The role of MicroRNA in autoimmunity, with special focus on Sjogren's syndrome, is discussed in this interesting article.

An investigation on whether TNF-like weak inducer of apoptosis (TWEAK) plays a role in cerebral involvement in human systemic lupus erythematosus and primary Sjögren's syndrome with neuropsychiatric implications. 

Discover who is talking about your research by accessing this web page by Altmetric. They track a range of sources to capture and collate activity concerning your publications.

Some researchers are studying the role of the vagus nerve (one of the cranial nerves that has gastric, respiratory and cardiovascular implications in the human body) in fatigue and tiredness in Sjogren's syndrome patients. True or not, the judge is still out there.

If you would like to know more on how I overcame tiredness and fatigue related to my Sjogren's by applying the Wim Hof method, please access this post.

Researchers published pertinent cardiovascular/oncology information in the British Medical Journal concerning the increased risk of lung cancer for those patients taking blood pressure medication, namely ARB and ACEI products (Portuguese language only).


Post image kindly obtained from Motor24, [https://www.motor24.pt/motores/ecologia/projeto-ecologico-ja-comecou-limpar-as-toneladas-plastico-do-oceano-pacifico/?utm_source=ojogo.pt&utm_medium=recomendadas&utm_campaign=afterArticle&_ga=2.151878137.1518736998.1536680189-840951596.1535967158].

Monday, 10 December 2018

Walkers launches recycling scheme after storm over crisp packets

"Walkers said packets kept the crisps fresher for longer and therefore cut food waste.

A recycling scheme for crisp packets has been launched by Walkers after it was targeted by protests on the issue.

Walkers was the focus of a campaign where its crisp packets were posted back to the snack firm, which led to problems at Royal Mail sorting offices.

Now the company said it had put in place collection points across the UK and also offers a free courier service.

Environmental group Beach Guardian welcomed the move, but said "the most vital thing is that people use it".

Leicester-based Walkers had faced months of criticism that its metallised plastic packets were contributing to litter and marine pollution.

Packets dating back decades were found on beaches, and a petition demanding environmentally-friendly packaging received more than 330,000 signatures.

Another campaign saw people encouraged to post packets back to Walkers, prompting Royal Mail to intervene as the plastic pouches were slowing down its systems.

The new recycling scheme was first announced in the summer, but is officially launched on Monday.

A spokesman for Walkers said: "Crisp packets are technically recyclable, the issue until now has been that they weren't being separated or collected for recycling.

"This scheme will tap into an established network of recycling collection points around the UK.

"It is simple and free to use, all brands of crisp packets will be accepted and will ultimately be turned into other basic plastic items."

It is planned the packets will be recycled into basic household items
Those who cannot get to a recycling centre can use a dedicated courier service free of charge, the company said.

Emily Stevenson, co-founder of Beach Guardian, said: "This scheme is a great step in the right direction. It gives people an option to dispose of their packets responsibly.

"Of course the most vital thing is that people use it."

Original article from the BBC News (HERE) published on the 10th of December 2018.

Post image kindly taken from TUCO, The University Caterers Organisation, [https://www.tuco.ac.uk/component/k2/item/285-walkers-crisps-to-create-uk-s-first-nationwide-recycling-scheme-for-crisp-packets].

Tuesday, 6 November 2018

Head to Alzheimer's, the putative link between a football career and neurocognitive diseases


I'm a crazy football-head! I breath, read, feed on everything that relates to football. I beg you to call it Football, not Soccer. Whoever came up with this name should be trialled!!! But I don't take offence easy so you're all excused as long as you keep reading to the end of this post. 

Every Saturday night I sit and watch this football TV show 'Match of the Day' that has been going on forever in the UK.  And as always Gary Lineker, a former football player that needs no introductions, is there with his guest panel criticising/acclaiming the weekend football results, goals, saves, performances, Mourinho's grumpiness :P and the like. The program is just that, a gourmet menu of football for football fans. But there was one specific moment in a random episode where they sat down for a while debating the possible link between a long football career, full of headings (head against ball) and concussions, and the onset of neurocognitive degeneration. Seriously! It got so interesting that time I just wanted to learn more about it. Would it be possible a link between neurocognitive degeneration and a career in football due to constantly heading balls? I had to research about it and I found a number of articles that can shed light on this topic but nothing immediately on heading balls. Surprisingly, I also found out that there's a lot of research emerging on this topic and soon certain observations will mature into consistent conclusions ready for discussion.  

 [B]

As I said just now I wasn't able to find many articles immediately relating football head injuries resulting from the recurrent heading of a football ball. In addition, the science out there is still dominated by American institutions and therefore pretty much everything found verses American Football (rugby with medieval plastic armours!!!). These were in my opinion the most interesting pieces I was able to read:

Guskiewicz et al (2005) [1] - Cerebral concussion is a recurrent injury in football but the neurological effects that occur as a result are yet not so clear. Some authors researched the relationship between previous head injuries and the probability of cognitive impairment/Alzheimer's disease by analysing a group of retired professional footballers who had had a previous head injury. After statistical study of the results observed (Chi square statistical test with two degrees of freedom negating a chance relationship) it was concluded that the occurrence of dementia-related syndromes 'may' be triggered by recurrent cerebral injuries resulting from a career in football. Retired players that had experienced 3 concussions had five times more prevalence of mild cognitive impairment and 3 times more the number of memory loss episodes. The authors could not establish a clear bridge between the series of concussions and Alzheimer's disease, but were able to hypothesise that for retired professional players who had these injuries Alzheimer's disease was happening earlier when compared to the general American male population.

Omalu et al (2005) [2] -  Case-studies always have their huge limitations, especially if not cross-linked with other more embracing studies to draw the most complete scenario, however, these authors analysed the full autopsy (with comprehensive neuropathological examination) results of a former football player that had been complaining of cognitive impairment, mood disorder and parkinsonian symptoms. The positive link between the long-term neurodegenerative outcomes was established with many cerebral observations (particularly with the presence of diffuse amyloid (protein) plaques - one of the Hallmark's of Alzheimer's disease as due to chronic brain trauma they accumulate as insoluble plaques between neurons, contrarily to what happens in healthy brains where these protein 'pieces' are metabolised and eliminated from the organism [3]. In fact, amyloid-beta plaques can be found in patients just a few hours after traumatic brain injury occurs, and the link between these protein plaques and Alzheimer's disease has been thoroughly studied (check Johnson et al (2010) [4] for an idea on the mechanics of this link). Nevertheless, the most surprising fact considering this player is that there was no family history of Alzheimer's disease and no records of him having had any head trauma outside his football career!!!

Small et al (2013) [5] - Five retired National football League players with ages going from 45 to 73 years old were studied using positron emission tomography (PET) with FDDNP (a molecule that binds to plaques (see [6] for more information on how the process goes mechanically) against five control subjects of comparable age, education and BMI (body mass index). Researchers analysed their PET signals in cortical and subcortical regions and came to the conclusion that, even though the results are for a very limited population and do not come along autopsy validation, FDDNP signals were higher in players in comparison to the healthy control subjects, in all the studied subcortical regions and in the amygdala -  the areas responsible for post-trauma tau deposition. Tau proteins are molecules that stabilise the microtubules in the nerve cells.

Many studies that are now arising on the mechanical damage of the brain have inherent methodological limitations. Hence, they must be taken merely as exploratory research. What does it mean? It means that these studies are merely tentative research studies to build up and interlink initial ideas that down the line will feed the very first dogmas/theories. Add to that a natural 'skepticism' from those who control the riches of the football market/organisation and you'll understand that even within NFL there is still some resistance in accepting the causal relation between consecutive head concussions and early cognitive decline later in life [7]. But the matter of fact is that there is definitely enough substance to at least indicate where the future research should go as results point towards a definitive incidence of cases where this link is scientifically verified and confirmed, as I have just explored above. Moreover, because not all players will immediately reveal signs of chronic traumatic encefalopathy [8] research out there needs to not only expand the range of observed population but also the depth of their scrutinising. For example, an interesting approach is the one taken by Marchi et al (2013) [9] where players were assessed after their matches took place and that allowed concluding that blood-brain barrier disruption occurred even in the absence of concussion, thus supporting the possibility that a long career of heading football balls could be linked to the early onset of Alzheimer's and other neurocognitive diseases.

I hope you've enjoyed today's post. Leave me a few comments or just drop a well-done message!

Any corrections or tips are also welcome.


[1] Guskiewicz, K. M., Marshall, S. W., Bailes, J. et al (2005). "Association between recurrent  concussion and late-life  cognitive impaiment in retired professional football players". Neurosurgery, 57(4), pp. 719-726.

[2] Omalu, B. I., DeKosky, S. T., Mynster, R. L. (2005). "Chronic traumatic encefalopathy in a National Football League player". Neurosurgery, 57(1). pp. 128-134.

[3] Amyloid plaques and neurofibrillary tangles, BrightFocus Foundation, [https://www.brightfocus.org/alzheimers/infographic/amyloid-plaques-and-neurofibrillary-tangles], last updated on the 21st of December 2017, last visited on the 1st of November 2018.

[4] Johnson, V. E., Stewart, W., Smith, D. H. (2010). "Traumatic brain injury and amyloid-beta pathology: a link to Alzheimer's disease?". Nature Reviews Neuroscience,11, pp. 361-370.

[5] Small,  G. W., Kepe, V., Siddhart, P. et al (2013). "PET scanning of brain Tau in retired National Football league players: Preliminary findings". The American Journal of Geriatric Psychiatry, 21(2), pp. 138-144.

[6] Ercoli, L. M.,  Siddarth, P., Kepe, V. et al (2009). "Differential FDDNP PET in non-demented middle aged and older adults". The American Journal of Geriatric Psychiatry, 17(5), pp. 397-406.

[7] Kain, D. J. (2009). "It's just a concussion: The National Football League's denial of a causal link between multiple concussions and later-life cognitive decline". HeinOnline [https://heinonline.org/HOL/LandingPage?handle=hein.journals/rutlj40&div=22&id=&page=], last visited on the 06-Nov-2018, last update unknown. 

[8] Hazrati, L-N., Tartaglia, M. C., Diamandis, P. et al (2013). "Absence of chronic traumatic encefalopathyin retired football players with multiple concussions and neurological symptomatology". Human Neuroscience, 7(222), pp. 1 -12.

[9] Marchi, N., Bazarian, J. J., Puvena, V. et al (2013). "Consequences of repeated blood-brain barrier disruption in football players". PLOS One, 8(3), pp. 1-11.

Post Photo by Kenny Webster on Unsplash

[B] Photo by John Torcasio on Unsplash

Wednesday, 6 June 2018

Pomegranate contamination kills woman in Australia

A cut pomegranate

Image copyrightEPA
Image captionAustralian authorities have linked 24 hepatitis A cases to a frozen pomegranate product
"An Australian woman has died after contracting hepatitis A from a packet of frozen pomegranate.
The 64-year-old died in South Australia last week in a "rare and tragic" case, state health authorities said.
Local officials issued a warning about the Australian-owned Creative Gourmet product in April. It has been linked to 24 cases of hepatitis A nationally.
Australians have been urged to check their freezers and discard packets of the frozen fruit.
About 2,000 packets of the Egyptian-grown pomegranate arils were sold. Fresh pomegranate and locally grown products were not affected, authorities said.
"The woman's death is the only death linked to this recalled product nationally to date," South Australia chief medical officer Prof Paddy Phillips said.
Most other people affected had made a full recovery and no further cases were expected, he said.
Hepatitis A, which attacks the liver, is usually spread through faecal matter, transmitted through sex or by touching contaminated food or objects.
It typically takes between 15 and 50 days to develop symptoms, which include nausea, fever and yellowing of the skin, local health authorities said.
Entyce Food Ingredients has said the contamination was linked to a "a relatively small batch" of its product.
Last year, the company was also forced to pull a selection of its frozen mixed berries products following another hepatitis A outbreak.

Original article on the BBC News website (access here).

Thursday, 24 May 2018

Memories might be transferred between generations through DNA

I know research on this matter is still early age, inconclusive and using models that can't be immediately related to humans (at least on the complex epigenetics bridge), but I have discussed this very same topic so many times with my wife. I always tell her - Rubbish DNA my as*, there's definitely a pool of acquired generational memories to unlock, tangled on what we stupidly call Rubbish DNA. Nature is way too sophisticated and tuned to waste energy on something irrelevant. There is always a better explanation for things when the human ego wants to excuse our ignorance on the universe out there and tag the object of our blatant lack of knowledge, of rubbish!!! Calling something we don't know about our genetics, of rubbish, is exactly like looking to the sky on a stormy day where thunder strikes the dry air and cry that the Gods are upset at us for not throwing them an adulation party :P

I still don't have the information to prove my point, but I believe others do share my view on this matter. But maybe this article by Houri-Ze'evi et al (2016) can start a very promising, interesting and much necessary debate. Times are exciting for science, especially for defining our human nature.


Don't mind 'too much' about the content of the video (I am sharing it as a starting point, an entry door to a discussion), I'm not the author but I do share his overall opinion on the matter. However, for the sake of scientific reliability, we all lack on solid proof for consubstantiation of our belief on this matter. But the debate has been triggered, What 'you think?

[1] Houri-Ze'evi, L., Korem, Y., Sheftel H et al (2016). "A tunable mechanism determines the duration of the transgenerationalsmall RNA inheritance in C. elegans". Cell, 165(1), pp. 88-99.

Post image kindly taken from Reset.Me [http://reset.me/story/science-proving-memories-passed-ancestors/].

Tuesday, 15 May 2018

TheToxicologistToday considered 3rd in the Top 20 Toxicology Blogs on the web

Feedspot, a modern RSS content reader for netizens who want or need to stay up-to-date with the most reliable and interesting content online, have emailed me with special congratulations. It happens that these information minions kindly attributed The Toxicologist Today a third place at the Top 20 Toxicology Blogs (see here). My humble toxicology blog made the podium with a 'bronze medal' that touched my heart, not because of the resonance/repercussion that such might have on my readers' count (if anything that will make me work more seriously towards increasing quality and entice level of my articles), but mostly because someone cared enough to analyse what I have been doing for pure love since August 2010. My small and honest contribution to a world with free scientific information for all - for education and information empower the public. 

Actually, some of the blogs that also made the list are advertised as interesting reads on the side columns of The Toxicologist Today. Some even operate on the realm of Forensic Toxicology, exactly the same area I recently produced a serious game for with SciBoard Games (see here for a short example). This honourable mention, in conjunction with the publishing of my very first digital science serious game "Adna's Lab" (download HERE and read more about it HERE) and the book I am writing on Nosocomial Infections, couldn't be a better bouquet of happiness for me.

I am aware that Feedspot might eventually gain from the fact that all those that made the list will propagate their name to the very four corners of the world (of this worldwide circle squareness), but free information is not easy to maintain or even share. I am more than happy to give Feedspot a hand for their capacity to browse through so many candidates and find value exactly on my work... and with such fierce competition that I am in total awe.


I am humbled, emotional and to a certain degree proud because my scientific passion is surfacing as a valued piece of informational work. I had to read and read and read it over and over again to make sure it wasn't a prank!!!! I thank Feedspot and will do my very best to try and maintain this blog of yours as the reliable source of information on Toxicology that I have been thriving for since 2010. Now go look below for the first 17 names of all blogs that made the top list (I will definitely add all of these links to my 'Interesting Reading column' the moment my professional life allows it).

3. The Toxicologist Today



Friday, 4 May 2018

Lidl offers locally grown cannabis to Swiss shoppers





"Supermarket takes advantage of law change to sell ‘relaxing’ tobacco alternative
Lidl’s cannabidiol products start £13.20 for a 1.5g box.
 Lidl’s cannabidiol products start £13.20 for a 1.5g box. Photograph: Lidl Schweiz

You may have heard about their cut-price stollen, and possibly their surprisingly flavoursome jam. But you probably won’t have sampled the latest range offered by the supermarket chain Lidl: locally grown cannabis. 
Two products derived from hemp flowers are being offered in Swiss stores as an alternative to rolling tobacco.
A 1.5g box, from plants grown indoors, costs 17.99 swiss francs (£13.20). A 3g bag is 19.99 Swiss francs, but is made from flowers grown in greenhouses.
The packs are on sale alongside cigarettes and cigars at the tills. The cost per cigarette is double that of tobacco roll-ups.
Switzerland changed the law in 2011 to permit people over 18 to purchase and use cannabis containing no more than 1% of tetrahydrocannabinol (THC), the plant’s principal psychoactive constituent.
Lidl’s products are designed to provide a relaxing and anti-inflammatory effect, but not to be intoxicating.
The German supermarket said its supplier – The Botanicals, based in Thurgau, north-east Switzerland – was growing the cannabis plants indoors and in semi-automated greenhouses





“The manufacturer relies on sustainable agriculture and refrains entirely from adding chemical, synthetic or genetically modified substances,” a statement said.
The product is said to be high on cannabidiol (CBD), an ingredient of the hemp plant. “The legally cultivable varieties contain only very small amounts of THC and a high proportion of CBD,” Lidl said.
Switzerland’s 2011 law change, designed to open up the availability of medicinal cannabis, has only recently been seized upon by commercial operators.
Switzerland’s customs agency, which collects taxes from cannabis product sales, recorded an increase in registered retailers from a “handful” in 2015 to more than 140 in the last year. In 2017 about £18m in tax was collected on sales of £73m.
The Swiss supermarket chain Coop - unrelated to the UK brand - was the first to sell cannabis cigarettes last year.
The charity Addiction Suisse has raised concern that CBD can modify the function of the placenta during pregnancy.
Lidl, one of the biggest supermarket brands in Europe, opened its 700th supermarket in the UK in February.

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Wednesday, 14 March 2018

Stephen Hawking: Visionary physicist dies aged 76


Read original piece at http://www.bbc.co.uk/news/uk-43396008

Read about the only book I read from his genius HERE.

Friday, 19 January 2018

Cancer blood test ‘enormously exciting’


Woman getting blood testImage copyrightGETTY IMAGES

Scientists have taken a step towards one of the biggest goals in medicine - a universal blood test for cancer.
A team at Johns Hopkins University has trialled a method that detects eight common forms of the disease.
Their vision is an annual test designed to catch cancer early and save lives. UK experts said it was "enormously exciting".
Tumours release tiny traces of their mutated DNA and proteins they make into the bloodstream.
The Cancer Seek test looks for mutations in 16 genes that regularly arise in cancer and eight proteins that are often released.
It was trialled on 1,005 patients with cancers in the ovary, liver, stomach, pancreas, oesophagus, colon, lung or breast that had not yet spread to other tissues.
Overall, the test found 70% of the cancers.
Dr Cristian Tomasetti, from Johns Hopkins University School of Medicine, told the BBC: "This field of early detection is critical, and the results are very exciting.
"I think this can have an enormous impact on cancer mortality."
The earlier a cancer is found, the greater the chance of being able to treat it.
Five of the eight cancers investigated have no screening programmes for early detection.
Pancreatic cancer has so few symptoms and is detected so late that four in five patients die in the year they are diagnosed.
Finding tumours when they could still be surgically removed would be "a night and day difference" for survival, said Dr Tomasetti.
Cancer Seek is now being trialled in people who have not been diagnosed with cancer.
This will be the real test of its usefulness.
The hope is it can complement other screening tools such as mammograms for breast cancer and colonoscopies for colorectal cancer.
Dr Tomasetti told the BBC: "We envision a blood test we could use once a year."

Universal test?

The Cancer Seek test, reported in the journal Science, is novel because it hunts for both the mutated DNA and the proteins.

breast cancer cellsImage copyrightSCIENCE PHOTO LIBRARY
Image captionBreast cancer can be detected by the new test

Increasing the number of mutations and proteins being analysed would allow it to test for a wider range of cancers.
Dr Gert Attard, team leader in the Centre for Evolution and Cancer at the Institute of Cancer Research, London, and consultant medical oncologist at the Royal Marsden NHS Foundation Trust, told the BBC: "This is of massive potential.
"I'm enormously excited. This is the Holy Grail - a blood test to diagnose cancer without all the other procedures like scans or colonoscopy."
He said "we're very close" to using blood tests to screen for cancer as "we have the technology".
But he cautioned there was still uncertainty about what to do when a cancer was diagnosed.
In some cases, the treatment may be worse than living with a cancer that is not immediately life-threatening.
Men can already have slow growing prostate cancers closely monitored rather than treated.
"When we detect cancer in a different way, we can't take for granted that everyone will need treatment," Dr Attard said.
The cost of Cancer Seek is less than $500 (£360) per patient, which is around the same price as a colonoscopy.
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